Chillicothe fire crews responded to the blaze in the early morning hours of Wednesday.
Investigators say a blaze at the former Union Station train depot off Chillicothe's East Main Street overpass is being investigated as arson.
Flames were seen shooting from the backside roof of the structure shortly after 4am, Wednesday.
It appeared Chillicothe firefighters had most of that fire knocked-down by about 4:30am, but the flames shot back up higher minutes later.
The Fire Department had trouble getting water to the building because on its location.The building's roof has been destroyed and heavy damage done to the structure's interior.
The fire Department confirmed the Fire started inside on the southeast corner on the first floor of the building.
The building was not occupied, and although the fire is under investigation, officials from the fire department have determined it to be an arson fire.
Union Station in Chillicothe was built between 1870-71 and had additions constructed during the Camp Sherman days of World War I.
Photos of the aftermath in daylight, by Kevin Coleman
The aerial ladder is used to knock out a flame-up in the second floor
The view of the roofless building from Main & Sugar streets
Firefighters attend to another flame-up at the back corner
Severe damage to a historic landmark
Demolition to the historic landmark